Scientific Name: Danio rerio
Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Actinopterygii-> Actinopteri-> Neopterygii-> Teleostei-> Osteoglossocephalai-> Clupeocephala-> Otomorpha-> Ostariophysi-> Otophysi-> Cypriniphysae-> Cypriniformes-> Cyprinoidei-> Danionidae-> Danioninae-> Danio
Summary: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008] [NCBI] [Proteinatlas]
Data set information
| Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
|---|---|---|---|---|---|---|
| Vthunter_1003 | 2017.09 | Smart-seq2 | KidneyMarrow | Normal | 245 | Link |
| Vthunter_110071 | 2019.12 | MARS-seq | TotalBrain | Normal | 1920 | Link |
Featureplot of receptors
Expression: Ubiquitous expression in skin (RPKM 9.8), esophagus (RPKM 9.6) and 23 other tissues
